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Abstract #0227

Multi-Center and Multi-Vendor Study of Long-TE 1H MRS at 3T for Detection of 2-Hydroxyglutarate in Brain Tumors In Vivo

Changho Choi1, Thomas Huber2, Anna Tietze3, Byung Se Choi4, Jung Hee Lee5, Seung-Koo Lee6, Alexander Lin7, and Sunitha Thakur8

1UT Southwestern Medical Center, Dallas, TX, United States, 2Technical University of Munich, Munich, Germany, 3Aarhus University Hospital, Aarhus, Denmark, 4Seoul National University College of Medicine, Seongnam, Korea, Republic of, 5Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, 6Yonsei University College of Medicine, Seoul, Korea, Republic of, 7Harvard Medical School, Boston, MA, United States, 8Memorial Sloan-Kettering Cancer Center, New York, NY, United States

The non-invasive identification of elevated 2-hydroxyglutarate (2HG) in IDH-mutated gliomas by 1H MRS in vivo is a major breakthrough in brain tumor research. Studies have shown that optimized long-TE approaches may confer advantages over short-TE MRS for detecting 2HG. Here we report an evaluation of the feasibility of long-TE 2HG MRS in Philips, Siemens and GE 3T scanners. Echo times were optimized, with numerical simulations and phantom validation, for the vendor-specific RF pulses. In-vivo data from IDH-mutated glioma patients, obtained in the three vendors, are discussed.

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