Abstract #0227

Multi-Center and Multi-Vendor Study of Long-TE 1H MRS at 3T for Detection of 2-Hydroxyglutarate in Brain Tumors In Vivo

Changho Choi¹, Thomas Huber², Anna Tietze³, Byung Se Choi⁴, Jung Hee Lee⁵, Seung-Koo Lee⁶, Alexander Lin⁷, and Sunitha Thakur⁸

¹UT Southwestern Medical Center, Dallas, TX, United States, ²Technical University of Munich, Munich, Germany, ³Aarhus University Hospital, Aarhus, Denmark, ⁴Seoul National University College of Medicine, Seongnam, Korea, Republic of, ⁵Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ⁶Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁷Harvard Medical School, Boston, MA, United States, ⁸Memorial Sloan-Kettering Cancer Center, New York, NY, United States

The non-invasive identification of elevated 2-hydroxyglutarate (2HG) in IDH-mutated gliomas by 1H MRS in vivo is a major breakthrough in brain tumor research. Studies have shown that optimized long-TE approaches may confer advantages over short-TE MRS for detecting 2HG. Here we report an evaluation of the feasibility of long-TE 2HG MRS in Philips, Siemens and GE 3T scanners. Echo times were optimized, with numerical simulations and phantom validation, for the vendor-specific RF pulses. In-vivo data from IDH-mutated glioma patients, obtained in the three vendors, are discussed.

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