Abstract #0228

Metabolic Profiling of Malignant Transformation and IDH-mutation in Diffuse Infiltrating Gliomas

Llewellyn Jalbert¹, Adam Elkhaled¹, Joanna J Phillips², Evan Neill³, Marram P Olson³, Mitchel S Berger⁴, John Kurhanewicz^1,3, Susan M Chang⁴, and Sarah J Nelson^1,3

¹Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States, ²Department of Pathology, University of California, San Francisco (UCSF), San Francisco, CA, United States, ³Department of Radiology & Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, CA, United States, ⁴Department of Neurological Surgery, University of California, San Francisco (UCSF), San Francisco, CA, United States

Patients diagnosed with infiltrating low-grade glioma have a relatively long survival, and a balance is often struck between treating the tumor and impacting quality of life. Aggressive treatments are typically reserved for lesions that have undergoing malignant transformation (MT) to a higher-grade lesion. Mutations in the isocitrate dehydrogenase 1 & 2 oncogenes and production of 2-hydroxyglutarate further characterize these tumors and are associated with improved outcome and treatment sensitivity. In this study, we found distinct metabolic profiles associated with patients' tumors that had undergone MT, as well as contained the IDH-mutated genotype, using proton HR-MAS spectroscopy.

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