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Abstract #0229

Noninvasive Assessment of IDH Mutational Status in Glioma using MR Elastography

Kay Pepin1, Arvin Arani1, Mona El Sheikh1, Nikoo Fattahi1, David Lake1, Armando Manduca1, Kiaran McGee1, Ian Parney1, Richard Ehman1, and John Huston1

1Mayo Clinic, Rochester, MN, United States

MR elastography (MRE) has been used to characterize the mechanical properties of normal and diseased brain tissue (1-4). This study evaluated MRE for the noninvasive characterization of gliomas, specifically investigating the relationship between tumor stiffness and mutations in the IDH1 gene, an important prognostic biomarker for improved outcome. Eighteen patients were enrolled in this study. MRE examinations were performed at 3T using an EPI-MRE sequence and 60Hz vibration frequency. Tumor stiffness was quantified and compared to IDH mutation status, as determined by histology. Twelve tumors were identified as IDH1 mutation positive and were significantly stiffer than tumors with non-mutated IDH1.

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