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Abstract #0236

Optimal time-window and perfusion protocol for MRI in early assessment of high grade glioma treatment response

Christopher Larsson1,2, Jonas Vardal1, Inge Rasmus Groote3, Magne Mørk Kleppestø1,2, Petter Brandal4, and Atle Bjørnerud1,5

1The Intervention Centre, Oslo University Hospital, Oslo, Norway, 2Faculty of Medicine, University of Oslo, Oslo, Norway, 3Department of Psychology, University of Oslo, Oslo, Norway, 4Department of Cancer Medicine, Surgery & Transplantation, Oslo University Hospital, Oslo, Norway, 5Faculty of Physics, University of Oslo, Oslo, Norway

Due to limitations in structural MRI in assessment of overall survival (OS) in high grade glioma interest in more advanced functional MRI methods has risen. A prospective longitudinal high grade glioma study including structural imaging and T1/T2* perfusion was performed in 27 patients to investigate the optimal time-window and most sensitive MRI perfusion method for early OS analysis.

No structural imaging, DSC or absolute perfusion parameter was found significant for early OS assessment. Change in median Ktrans and CBF from baseline to eight weeks was found significant and CBF change >15% most accurate predictor for poor OS.

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