Abstract #0237

Association between cortical demyelination and structural connectomics in early multiple sclerosis

Gabriel Mangeat^1,2, Russell Ouellette^2,3, Constantina Andrada Treaba^2,3, Tobias Granberg^2,3, Elena Herranz^2,3, Celine Louapre^2,3, Nikola Stikov^1,4, Jacob A. Sloane^3,5, Eric C. Klawiter^2,3,6, Caterina Mainero^2,3, and Julien Cohen-Adad^1,7

¹Polytechnique Montreal, Montreal, QC, Canada, ²Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Montreal Health Institute, Montreal, QC, Canada, ⁵Beth Israel Deaconess Medical Center, Boston, MA, United States, ⁶Department of Neurology, MGH, Boston, MA, United States, ⁷CRIUGM, Functional Neuroimaging Unit, Université de Montréal, Montreal, QC, United States

Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by diffuse abnormalities along white matter tracts and demyelination, including cortical lesions. In this study, we explored the interplay between cortical and brain structural networks integrity in a cohort of early MS subjects by combining quantitative mapping of T₂* and T₁ relaxation rates from 7T MRI acquisitions to measure cortical demyelination with diffusion imaging and graph theory to assess the structural brain architecture. Results suggest that motor, premotor and anterior cingulate cortices are affected simultaneously by cortical demyelination and connectomics alterations, at a very early stage of MS.

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