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Abstract #0238

Cerebellar-cerebral connections with the default mode network influence working memory performance in MS

Giovanni Savini1,2, Matteo Pardini3, Alessandro Lascialfari1,4, Declan Chard5, David Miller5, Egidio D'Angelo2,6, and Claudia Angela Michela Gandini Wheeler-Kingshott2,5

1Department of Physics, University of Milan, Milan, Italy, 2Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy, 3Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy, 4Department of Physics, University of Pavia, Pavia, Italy, 5NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL, Institute of Neurology, University College London, London, United Kingdom, 6Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

The cerebellum is linked to the default mode network (DMN) and its contribution to non-motor functions is now increasingly recognized. In Multiple Sclerosis (MS) motor and cognitive functions are both impaired. Here we aimed at assessing a possible link between cognition and cerebellar-cerebral fibers disruption in MS. Probabilistic tractography and graph theory derived metrics were compared to Symbol Digit Modalities Test (SDMT) scores in MS. We found that accounting for cerebellar-cerebral connections when calculating DMN graph metrics yielded a stronger correlation between network efficiency and SDMT scores, suggesting that disruption of the cerebellar-cerebral connections has significant cognitive consequences in MS.

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