Abstract #0239

Outer and inner cortical MTR abnormalities observed in clinically isolated syndromes

Rebecca Sara Samson¹, Manuel Jorge Cardoso^2,3, Wallace J Brownlee¹, J William Brown^1,4, Matteo Pardini⁵, Sebastian Ourselin^2,3, Claudia Angela Michela Gandini Wheeler-Kingshott^1,6, David H Miller^1,7, and Declan T Chard^1,7

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom, ²Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, London, United Kingdom, ³Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom, ⁴Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ⁵Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy, ⁶Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy, ⁷National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, London, United Kingdom

Cortical magnetization transfer ratio (cMTR) is potentially a sensitive measure of pathology linked with disease progression in relapse-onset multiple sclerosis (MS). We investigated outer cMTR changes in people following a clinically isolated syndrome (CIS), and compared those who later developed MS with those who did not. Compared with controls, the outer-to-inner cMTR ratio was significantly lower in patients who developed MS after 15 years but not in those who remained CIS. This suggests that the pathological processes underlying preferential reductions in outer cMTR start early in the clinical course of MS, and may be relevant to conversion to MS.

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