Abstract #0243

Dissociated longitudinal patterns of neural activation, functional connectivity and structural connectivity in a mouse model of de- and re-myelination

Yi-Ching Lynn Ho^1,2, Fiftarina Puspitasari¹, Way-Cherng Chen¹, and Kai-Hsiang Chuang¹

¹Singapore Bioimaging Consortium, Agency for Science, Technology & Research (A*STAR), Singapore, Singapore, ²Interdisciplinary Institute of Neuroscience & Technology (ZIINT), Zhejiang University, Hangzhou, China, People's Republic of

We hypothesized that structure and functional responses do not demonstrate the same pattern of impairment across time. Using the cuprizone mouse model of reversible demyelination, we show different longitudinal patterns of neural activation and functional connectivity, compared to healthy mice and also to the extent of cuprizone demyelination.

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