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Abstract #0243

Dissociated longitudinal patterns of neural activation, functional connectivity and structural connectivity in a mouse model of de- and re-myelination

Yi-Ching Lynn Ho1,2, Fiftarina Puspitasari1, Way-Cherng Chen1, and Kai-Hsiang Chuang1

1Singapore Bioimaging Consortium, Agency for Science, Technology & Research (A*STAR), Singapore, Singapore, 2Interdisciplinary Institute of Neuroscience & Technology (ZIINT), Zhejiang University, Hangzhou, China, People's Republic of

We hypothesized that structure and functional responses do not demonstrate the same pattern of impairment across time. Using the cuprizone mouse model of reversible demyelination, we show different longitudinal patterns of neural activation and functional connectivity, compared to healthy mice and also to the extent of cuprizone demyelination.

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