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Abstract #0244

Hyperpolarized 13C MRSI can detect neuroinflammation in vivo in a Multiple Sclerosis murine model

Caroline Guglielmetti1,2, Chloe Najac1, Annemie Van der Linden2, Sabrina M Ronen1, and Myriam M Chaumeil1

1University of California San Francisco, San Francisco, CA, United States, 2University of Antwerp, Antwerp, Belgium

This study demonstrates that 13C MRS of hyperpolarized pyruvate can be used to detect increased lactate production from pro-inflammatory macrophages, mechanism mediated by pyruvate dehydrogenase kinase-1 upregulation and pyruvate dehydrogenase inhibition, in a preclinical model of multiple sclerosis, hence providing a novel tool for in-vivo detection of neuroinflammation.

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