Abstract #0256

Rapid Two-Step QSM Without A Priori Information

Christian Kames^1,2, Vanessa Wiggermann^1,3,4, and Alexander Rauscher^1,4

¹UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ²Department of Engineering Physics, University of British Columbia, Vancouver, BC, Canada, ³Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁴Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada

Current state-of-the-art QSM reconstruction algorithms are plagued by the trade-off between reconstruction speed and quality. We propose a novel two-step dipole inversion algorithm 20x faster than MEDI and HEIDI, while producing qualitatively appealing images with a root-mean-square error less than MEDI’s and HEIDI’s when compared to COSMOS. The proposed method works by first reconstructing the well-conditioned k-space region through the use of a Krylov subspace solver, followed by a total variation minimization to fill in the ill-conditioned k-space region.

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