Abstract #0259

Gender Differences in Sodium Deposition in Muscle and Skin

Ping Wang^1,2, Muge Serpil Deger³, Hakmook Kang⁴, T. Alp Ikizler³, Jens M. Titze⁵, and John C. Gore^1,2

¹Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States

Sodium ions play a vital role in cellular homeostasis and electrochemical activity throughout the human body. Previous studies have measured muscle and skin sodium contents in vivo in humans using MRI and have shown characteristic changes with age and as a result of pathological changes. In this study, we found significant gender differences in sodium deposition between muscle and skin, with male has higher sodium content in skin than in muscle, while female has higher muscle sodium than skin sodium. This observation seems to be more reliable with the increase of age.

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