Abstract #0258

Quantitative Muscle Perfusion with DCE-MRI Shows Distinct Load-Dependent Exercise-Stimulated Muscle Perfusion Patterns

Jeff L. Zhang¹, Christopher Hanrahan¹, Christopher C. Conlin¹, Corey Hart², Gwenael Layec², Kristi Carlston¹, Daniel Kim¹, Michelle Mueller³, and Vivian S. Lee¹

¹Radiology, University of Utah, Salt Lake City, UT, United States, ²Internal Medicine, University of Utah, Salt Lake City, UT, United States, ³Vascular surgery, University of Utah, Salt Lake City, UT, United States

Noninvasive mapping of calf muscle perfusion with high spatial resolution has potential for assessing the severity of peripheral artery disease (PAD) and studying associated capillary density abnormality. We tested our novel DCE-MRI method to measure calf muscle hyperemia stimulated by plantar flexion at three different workloads. Increases in exercise load caused increased total perfusion in gastrocnemius, with a heterogeneous pattern at medium load and homogeneous at higher load. Perfusion in soleus did not increase until very heavy load of 16 lbs. DCE-MRI provides high spatial resolution measurement of post-exercise muscle perfusion.

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