Abstract #0266

Measurement of proteoglycan concentration in intervertebral discs assessed by 1HMRS at 1.5T

Lisa Maria Harris^1,2, Ella Hodder^2,3, Mara Cercignani², Jan Bush², Derek Convill³, Paul Colley¹, and Nicholas Dowell²

¹Radiological Sciences, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom, ²Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, ³Computing, Engineering and Mathematics, University of Brighton, Brighton, United Kingdom

An assessment was made to determine whether proteoglycan concentration could accurately be quantified at 1.5T using 1HMRS in a group of 13 healthy volunteers. A peak from the N-acetyl resonance associated with proteoglycan was seen in all thirteen spectra, and reliably measured (308.8±59.9). This compares favourably with studies performed at higher field strengths, thus showing that is it possible even at 1.5T to measure proteoglycans in intervertebral discs.

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