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Abstract #0266

Measurement of proteoglycan concentration in intervertebral discs assessed by 1HMRS at 1.5T

Lisa Maria Harris1,2, Ella Hodder2,3, Mara Cercignani2, Jan Bush2, Derek Convill3, Paul Colley1, and Nicholas Dowell2

1Radiological Sciences, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom, 2Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 3Computing, Engineering and Mathematics, University of Brighton, Brighton, United Kingdom

An assessment was made to determine whether proteoglycan concentration could accurately be quantified at 1.5T using 1HMRS in a group of 13 healthy volunteers. A peak from the N-acetyl resonance associated with proteoglycan was seen in all thirteen spectra, and reliably measured (308.8±59.9). This compares favourably with studies performed at higher field strengths, thus showing that is it possible even at 1.5T to measure proteoglycans in intervertebral discs.

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