Abstract #0273

Simultaneous evaluation of hemodynamic and functional connectivity in patients with chronic steno-occlusive disease of the cerebrovascular system: A study using BOLD with acetazolamide

Junjie Wu¹, Seena Dehkharghani¹, Tyler Gleason¹, Fadi Nahab², and Deqiang Qiu¹

¹Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, ²Department of Neurology, Emory University, Atlanta, GA, United States

In this paper we applied a temporal-shift analysis of the BOLD signal to delineate regions with abnormal perfusion in patients with chronic steno-occlusive disease of the cerebrovascular system. We proposed an improved method of analysis based on an iterative approach for the temporal shift analysis. We further explored the effects of acetazolamide, a vasodilator, on the assessment of hemodynamic compromise using temporal-shift analysis and functional connectivity.

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