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Abstract #0280

Real-time fMRI Neurofeedback with Simultaneous EEG in Combat-related PTSD: Frontal EEG Asymmetry Variations as Measure of Treatment Response

Vadim Zotev1, Raquel Phillips1, Masaya Misaki1, Chung Ki Wong1, Brent Wurfel1, Matthew Meyer1,2, Frank Krueger1,3, Matthew Feldner1,4, and Jerzy Bodurka1,5

1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, 3Neuroscience Dept., George Mason University, Fairfax, VA, United States, 4Dept. of Psychological Science, University of Arkansas, Fayetteville, AR, United States, 5College of Engineering, University of Oklahoma, Tulsa, OK, United States

We have performed a study of emotion regulation training in veterans with combat-related PTSD using real-time fMRI neurofeedback (rtfMRI-nf) with simultaneous EEG. Fifteen PTSD patients learned to upregulate their left amygdala activity using rtfMRI-nf during a positive emotion induction task based on retrieval of happy autobiographical memories. Individual session-to-session variations in frontal EEG asymmetry (FEA) changes during the rtfMRI-nf task significantly correlated with variations in PTSD severity (CAPS) and co-morbid depression severity (HDRS). These results suggest that variations in task-specific FEA changes during rtfMRI-nf training provide a sensitive measure of individual response to treatment in PTSD patients.

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