Abstract #0281

In-vivo detection of neuronal current using spin-lock oscillatory excitation at 7T

Yuhui Chai¹, Guoqiang Bi², Liping Wang³, Fuqiang Xu⁴, Xin Zhou⁴, Bensheng Qiu², Hao Lei⁴, Bing Wu⁵, Yang Fan⁵, and Jia-Hong Gao¹

¹Center for MRI Research, Peking University, Beijing, China, People's Republic of, ²University of Science and Technology of China, Hefei, China, People's Republic of, ³Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, People's Republic of, ⁴Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China, People's Republic of, ⁵GE Healthcare, MR Research China, Beijing, China, People's Republic of

In-vivo detection of neuronal current remains a challenging and promising goal in fMRI. Previous work has demonstrated its feasibility in phantom and cell culture studies, but attempts in in-vivo studies remain few and far between. As neuronal current is usually comprised of a series of oscillatory waveforms rather than being a direct current, it is most likely to be detected using oscillatory current sensitive sequences. In this study, we explored the potential of using the spin-lock oscillatory excitation (SLOE) sequence to directly detect optogenetically evoked oscillatory neuronal current in vivo for the first time.

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