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Abstract #0283

Transcranial MRI-Guided High-Intensity Focused Ultrasound for Treatment of 
Essential Tremor: Initial Clinical Experience and Correlation of Clinical Outcome with Lesion Size, Localization, and Dose

Christian Federau1, Maged Goubran1, Jason Su1, Jaimie Henderson1, Veronika Santini1, Casey Harrison Halpern1, Brian Rutt1, Kim Butts Pauly1, and Pejman Ghanouni1

1Stanford University, Stanford, CA, United States

Transcranial MR-guided high-intensity focused ultrasound ablation of the ventral division of the ventral lateral posterior thalamic nucleus (VLpv) is a promising, minimally invasive treatment method for essential tremor. We report our initial clinical experience in 11 patients, and correlate clinical outcome with lesion size, location, and thermal dose during treatment. We found a correlation between clinical outcome at 1 year follow-up and lesion size (r = 0.73), as well as thermal dose in the VLpv (r = 0.65).

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