Tracy L Luks1, Tracy Richmond McKnight1, Aurelia Williams1, Evan Neill1, Khadjia Lobo1, Anders Persson2, Arie Perry3, Joanna Phillips3, Annette Molinaro4, Susan Chang4, and Sarah J Nelson1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Neurology, University of California San Francisco, San Francisco, CA, United States, 3Pathology, University of California San Francisco, San Francisco, CA, United States, 4Neurosurgery, University of California San Francisco, San Francisco, CA, United States
Invivo MR anatomy, diffusion, perfusion, and
spectroscopy profiles from non-enhancing grade 2 and grade 3 gliomas were
examined by histologic and molecular characteristics associated with clinical
outcome. Patients underwent a pre-surgical 3T MR exam including IRSPGR, FSE, FLAIR,
DWI, MRSI and DSC. For surgical biopsies, histological sub-type, grade, cleaved
caspase-3, MIB-1, Ki67, IDH1R132H, ATRX, p53, and co-deletion of 1p19q were
determined. Overall, molecular characteristics associated with worse clinical
outcome were associated with higher ADC and lower FA, lower nCBV and nPH, and
higher Recov, and higher nLAC.
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