Abstract #0294

Radiomic features from the necrotic region on post-treatment Gadolinium T1w MRI appear to differentiate pseudo-progression from true tumor progression in primary brain tumors

Prateek Prasanna¹, Raymond Huang², Andrew Rose¹, Gagandeep Singh¹, Anant Madabhushi¹, and Pallavi Tiwari¹

¹Case Western Reserve University, Cleveland, OH, United States, ²Brigham and Women's Hospital, Boston, MA, United States

Pseudoprogression is an early-delayed inflammatory response to chemoradiotherapy typically appearing up to 3 months post-treatment in brain tumors. On routine MRI, pseudoprogression closely mimics the appearance of true progression, thereby making their visual identification challenging. Early diagnosis of pseudoprogression has implications in management of treatment effects and subsequently survival. We present initial results of using a newly developed radiomic descriptor, CoLlAGE, in distinguishing the two pathologies. We report that CoLlAGe measurements when captured from the necrotic region as opposed to just the enhancing region on MRI can reliably distinguish psuedo-progression from true progression with 100% accuracy (n=17)

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