Abstract #0295

Combined assessment of tumor oxygen metabolism and angiogenesis in glioma patients

Andreas Stadlbauer¹, Max Zimmermann¹, Karl Rössler¹, Stefan Oberndorfer², Arnd Dörfler³, Michael Buchfelder¹, and Gertraud Heinz⁴

¹Department of Neurosurgery, University of Erlangen, Erlangen, Germany, ²Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria, ³Department of Neuroradiology, University of Erlangen, Erlangen, Germany, ⁴Department of Radiology, University Clinic of St. Pölten, St. Pölten, Austria

Reprogramming energy metabolism and inducing angiogenesis are part of the hallmarks of cancer. Thirty-five patients with untreated or recurrent glioma were examined using vascular architecture mapping (VAM) and the multiparametric quantitative BOLD (mp-qBOLD) technique for combined exanimation of oxygen metabolism and angiogenesis in gliomas. Maps of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO₂) as well as of the vascular architecture MRI biomarkers microvessel radius (R_U), density (N_U), and type indicator (MTI) were calculated. Low-grade glioma showed increased OEF. Glioblastomas showed significantly increased CMRO₂ and N_U. MTI demonstrated widespread areas draining venous microvasculature in high-grade gliomas.

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