Abstract #0296

Radiogenomics by Proton Magnetic Resonance Spectroscopy: Integrative Analysis of Metabolites and Genome-wide Expression in Glioblastomas

Dieter Henrik Heiland¹, Thomas Lange², Ralf Schwarzwald³, Dietmar Pfeifer⁴, Karl Egger³, Horst Urbach³, Astrid Weyerbrock¹, and Irina Mader³

¹Dept. of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, ²Dept. MR Physics, Dept. of Radiology, University Medical Center Freiburg, Freiburg, Germany, ³Dept. of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany, ⁴Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany

The purpose of this work was to search for a connection between metabolites observed by proton magnetic resonance spectroscopy of glioblastomas and tumor genetics. Two specific pathways could be identified, one belonging to NAA and discriminating an astroglial versus oligo/neural subgroup. Another one was related to Cr also distinguishing between two subgroups, one attributed to apoptosis and another one to the PI3K-AKT-mTOR signaling cascade.

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