Abstract #0296

Radiogenomics by Proton Magnetic Resonance Spectroscopy: Integrative Analysis of Metabolites and Genome-wide Expression in Glioblastomas

Dieter Henrik Heiland¹, Thomas Lange², Ralf Schwarzwald³, Dietmar Pfeifer⁴, Karl Egger³, Horst Urbach³, Astrid Weyerbrock¹, and Irina Mader³

¹Dept. of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, ²Dept. MR Physics, Dept. of Radiology, University Medical Center Freiburg, Freiburg, Germany, ³Dept. of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany, ⁴Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany

The purpose of this work was to search for a connection between metabolites observed by proton magnetic resonance spectroscopy of glioblastomas and tumor genetics. Two specific pathways could be identified, one belonging to NAA and discriminating an astroglial versus oligo/neural subgroup. Another one was related to Cr also distinguishing between two subgroups, one attributed to apoptosis and another one to the PI3K-AKT-mTOR signaling cascade.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.