Abstract #0302

Separation of intracellular and extracellular Z-spectra by DiffusionCEST

Kevin Ray¹, Gogulan Karunanithy², Andrew Baldwin², Michael Chappell³, and Nicola Sibson¹

¹Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, ²Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, United Kingdom, ³Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

CEST-MRI is an imaging technique which is sensitive to tissue pH, and has generated pH-weighted images in acute stroke patients. One key assumption regarding CEST-MRI is that the signal is predominantly intracellular. This assumption has implications in the application of CEST-MRI for pH measurement of tumours, which are generally associated with extracellular acidosis. This study developed a novel pulse sequence, combining stimulated echo acquisition mode diffusion and CEST imaging. Using this novel pulse sequence, the intracellular and extracellular contributions to the acquired Z-spectrum were isolated in a simple cell system and post-mortem mouse brain.

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