Abstract #0301

Blind Compressed Sensing-based Ultrafast Chemical Exchange Saturation Transfer (CEST) Imaging

Hye-Young Heo^1,2, Sampada Bhave³, Mathews Jacob³, and Jinyuan Zhou^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States

CEST imaging, such as amide proton transfer (APT) imaging, is a novel, clinically valuable molecular MRI technique that can give contrast due to a change in water signal caused by chemical exchange with saturated solute protons. However, its clinical translation is still limited by its relatively long scan time because a series of RF saturation frequencies are unavoidably acquired. Here, we present a highly accelerated CEST imaging technique (up to 10-fold) using a novel blind compressed sensing framework.

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