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Abstract #0301

Blind Compressed Sensing-based Ultrafast Chemical Exchange Saturation Transfer (CEST) Imaging

Hye-Young Heo1,2, Sampada Bhave3, Mathews Jacob3, and Jinyuan Zhou1,2

1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States

CEST imaging, such as amide proton transfer (APT) imaging, is a novel, clinically valuable molecular MRI technique that can give contrast due to a change in water signal caused by chemical exchange with saturated solute protons. However, its clinical translation is still limited by its relatively long scan time because a series of RF saturation frequencies are unavoidably acquired. Here, we present a highly accelerated CEST imaging technique (up to 10-fold) using a novel blind compressed sensing framework.

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