Abstract #0311

Low Frequency Optogenetic Stimulation of Dentate Gyrus Enhances Brain Functional Connectivity Revealed by Resting-State fMRI

Russell W Chan^1,2, Alex TL Leong^1,2, Patrick P Gao^1,2, Y S Chan³, W H Yung⁴, Kevin K Tsia², and Ed X Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, People's Republic of, ²Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, People's Republic of, ³School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China, People's Republic of, ⁴School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China, People's Republic of

Low frequency coherent rsfMRI signals (<0.1Hz) do not match the bandwidth of established neuronal oscillations, highlighting a gap in our knowledge regarding the neuronal basis of rsfMRI underlying long-range brain networks. In this study, optogenetics and rsfMRI were combined to investigate the neuronal basis of rsfMRI connectivity by probing alternations of brain functional connectivity before, during and after low frequency stimulation in dorsal dentate gyrus. Our results demonstrated that low frequency optogenetic stimulation enhanced brain functional connectivity. This indicated that low frequency neuronal oscillations contribute and underlie the synchronized long-range rsfMRI brain functional networks.

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