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Abstract #0312

Functional MRI reveals striatal–thalamic connectivity in cognitive neural behavior altered by central thalamic deep brain stimulation

Hsin-Yi Lai1, Hui-Ching Lin2,3, Yu-Chun Lo4, Lun-De Liao5,6, Wei-Che Wei7, and You-Yin Chen7

1Interdisciplinary Institute of Neuroscience and Technology (ZIINT), Zhejiang University, Hangzhou City, China, People's Republic of, 2Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan, 3Brain Research Center, National Yang Ming University, Taipei, Taiwan, 4Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan, 5Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County, Taiwan, 6Singapore Institute for Neurotechnology, National University of Singapore, Singapore, Singapore, 7Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan

This study demonstrates neuronal striatal–thalamic connectivity modulated by direct stimulating the central thalamus in rats. Our results indicate that the CT-DBS modulate the neuronal activity in bilateral anterior cingulate cortex, caudate-putamen and somatosensory cortex and increases in functional connectivity between the striatum and parafascicular thalamic nucleus, hippocampus and primary motor cortex to shorten the cognitive related behavior task. CT-DBS fMRI has potential to explore functional connectivity in the brain and monitor functional plasticity changes in a specific neuroanatomical pathway in vivo.

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