Abstract #0313

The structural basis for supporting functional connectivity in mice

Joanes Grandjean¹, Valerio Zerbi², Nicole Wenderoth², and Markus Rudin¹

¹University and ETH Zurich, Zurich, Switzerland, ²ETH Zurich, Zurich, Switzerland

Connectomics holds promise to foster our understanding of the healthy and disordered brain. MRI has been the method of choice for such analysis, combining diffusion weighted with functional imaging to resolve structural and functional connectivity, respectively. However, both methods are indirect measures prone to bias and artifacts. In mice, structural connectivity has been reconstructed with high spatial resolution by mapping the distribution of viral tracers following local injections at multiple sites offering a unique opportunity to compare functional connectivity with detailed mono-synaptic projections. Such comparisons should help bridging functional and structural connectivity in rodents with implications for human studies.

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