Abstract #0314

Characterization of acute phencyclidine-induced dose-dependent schizophrenic symptoms in rat: relationship between functional connectivity, hemodynamic response, behavior, and neurotransmitter levels

Jaakko Paasonen¹, Raimo A Salo¹, Jouni Ihalainen², Juuso Leikas², Katja Savolainen², Markus M Forsberg², and Olli Gröhn¹

¹Department of Neurobiology, University of Eastern Finland, Kuopio, Finland, ²School of Pharmacy, University of Eastern Finland, Kuopio, Finland

Schizophrenia is a disorder that lack effective medication. In order to improve treatments, better disease models are required. Here, phencyclidine (PCP)-induced schizophrenic symptoms were investigated in rats with fMRI. Results were compared with microdialysis measurements and behavioral tests. At PCP doses ≥ 3 mg/kg, characteristics for psychotic symptoms were detected in functional connectivity (FC), having good correspondence with locomotor and dopamine activity. With PCP doses ≤ 2 mg/kg, markers for psychotic symptoms were absent. The FC of mesolimbic pathway was still affected, and social and cognitive deficits were confirmed in behavioral tests. Thus, PCP ≤ 2 mg/kg induces specifically the social and cognitive schizophrenic deficits.

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