Abstract #0315

ACC GABA levels predict activity and connectivity in the fronto-striatal network during interference inhibition in borderline personality disorder

Guoying Wang¹, Julia van Eijk¹, Traute Demirakca¹, Markus Sack¹, Sylvia Cackowski², Annegret Krause-Utz², Christian Schmahl², and Gabriele Ende ¹

¹Neuroimaging, Central Institute of Mental Health, Mannheim, Germany, ²Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany

By combining the MRS and fMRI technique, we tested whether ACC GABA levels would predict the activity and connectivity in fronto-striatal networks during interference inhibition (Simon task) in BPD patients. BPD patients showed a significant positive correlation between ACC GABA levels and BOLD responses in fronto-striatal regions during interference inhibition. Additionally, ACC GABA levels in BPD patients were positively related to ACC-caudate functional connectivity during the incongruent condition. Our findings highlight that the GABAergic system in the ACC plays an important role in the modulation of impulsivity via regulating the local neural activity and remote connectivity between key regions.

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