Guoying Wang1, Julia van Eijk1, Traute Demirakca1, Markus Sack1, Sylvia Cackowski2, Annegret Krause-Utz2, Christian Schmahl2, and Gabriele Ende 1
1Neuroimaging, Central Institute of Mental Health, Mannheim, Germany, 2Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
By combining the MRS and fMRI technique, we tested
whether ACC GABA levels would predict the activity and connectivity in fronto-striatal
networks during interference inhibition (Simon task) in BPD patients. BPD
patients showed a significant positive correlation between ACC GABA levels and BOLD
responses in fronto-striatal regions during interference inhibition.
Additionally, ACC GABA levels in BPD patients were positively related to
ACC-caudate functional connectivity during the incongruent condition. Our
findings highlight that the GABAergic system in the ACC plays an important role
in the modulation of impulsivity via regulating the local neural activity and
remote connectivity between key regions.