Abstract #0316

Fluctuations in Functional Connectivity Predict Shifts in Arousal State

Chenhao Wang¹, Ju Lynn Ong¹, Amiya Patanaik¹, Juan Zhou^1,2, and Michael W. L. Chee¹

¹Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore, ²Clinical Imaging Research Center, Agency for Science, Technology and Research, Singapore, Singapore

To elucidate relationship between fluctuation in functional connectivity and behavior we estimated dynamic connectivity states (DCS) from task-free fMRI obtained from sleep-deprived healthy young adults. Using spontaneous eye closures as a proxy for vigilance, we identified two DCS that were associated with high and low arousal respectively. DCS exhibiting similar connectivity patterns were also observed when individuals were performing an auditory vigilance task. Dwell time in high or low arousal DCS predicted task performance. Additionally, fluctuations in DCS and task response time were correlated. Fluctuations in functional connectivity appear to be related to spontaneous changes in arousal that affect vigilance.

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