Abstract #0319

Pressure Gradient Measurement in the Coronary Artery Using Phase Contrast (PC)-MRI: Initial Patient Results Towards Noninvasive Quantification of Fractional Flow Reserve

Zixin Deng^1,2, Sangeun Lee³, Zhaoyang Fan¹, Christopher Nguyen¹, Iksung Cho³, Qi Yang¹, Xiaoming Bi⁴, Byoung-Wook Choi⁵, Jung-Sun Kim³, Daniel Berman¹, Hyuk-Jae Chang³, and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Cardiology, Severance Hospital, Yonsei Univeristy College of Medicine, Seoul, Korea, Republic of, ⁴R&D, Siemens Healthcare, Los Angeles, CA, United States, ⁵Radiology, Severance Hospital, Yonsei Univeristy College of Medicine, Seoul, Korea, Republic of

Fractional flow reserve is an invasive diagnostic tool to evaluate the functional significance of a coronary stenosis by quantifying the pressure gradient (ΔP) across the stenosis. We proposed a non-invasive technique to derive ΔP using Phase-contrast (PC)-MRI in conjunction with the Navier-Stokes equations (ΔP_MR). Excellent correlation was observed between derived ΔP_MR and measure ΔP from a pressure transducer in a small caliber phantom model. A significant increase in ΔP_MR was seen in the patient group vs. healthy controls. Preliminary results suggested that noninvasive quantification of ΔP_MR in coronary arteries is feasible.

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