Abstract #0327

UK Biobank: Brain imaging protocols and first data release

Karla L Miller¹, Neal K Bangerter², Fidel Alfaro Almagro¹, David L Thomas³, Essa Yacoub⁴, Junqian Xu⁵, Andreas J Bartsch^1,6, Saad Jbabdi¹, Stamatios N Sotiropoulos¹, Mark Jenkinson¹, Jesper Andersson¹, Ludovica Griffanti¹, Peter Weale⁷, Iulius Dragonu⁷, Steve Garratt⁸, Sarah Hudson⁸, Rory Collins^8,9, Paul M Matthews¹⁰, and Stephen M Smith¹

¹FMRIB Centre, University of Oxford, Oxford, United Kingdom, ²Electrical and Computer Engineering, Brigham Young University, Provo, UT, United States, ³Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, ⁴Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ⁵Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁶Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany, ⁷Siemens Healthcare (UK), London, United Kingdom, ⁸UK Biobank Ltd, Stockport, United Kingdom, ⁹Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom, ¹⁰Department of Medicine, Imperial College London, London, United Kingdom

UK Biobank is a prospective epidemiological study of 500,000 participants consisting of extensive questionnaires, physical measures and biological samples, linking to long-term health outcomes. The imaging extension for the UK Biobank ultimately aims to image 100,000 subjects from this cohort, including brain, cardiac and body MRI, bone scans and carotid ultrasound. We overview the brain imaging component, which includes structural, functional and diffusion MRI. The value of this open resource arises not only from multi-modal/multi-organ imaging, but also from the depth of other demographic, phenotypic and exposure data, and will increase over time as clinical outcomes are realized in the population.

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