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Abstract #0327

UK Biobank: Brain imaging protocols and first data release

Karla L Miller1, Neal K Bangerter2, Fidel Alfaro Almagro1, David L Thomas3, Essa Yacoub4, Junqian Xu5, Andreas J Bartsch1,6, Saad Jbabdi1, Stamatios N Sotiropoulos1, Mark Jenkinson1, Jesper Andersson1, Ludovica Griffanti1, Peter Weale7, Iulius Dragonu7, Steve Garratt8, Sarah Hudson8, Rory Collins8,9, Paul M Matthews10, and Stephen M Smith1

1FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2Electrical and Computer Engineering, Brigham Young University, Provo, UT, United States, 3Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, 4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 5Icahn School of Medicine at Mount Sinai, New York, NY, United States, 6Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany, 7Siemens Healthcare (UK), London, United Kingdom, 8UK Biobank Ltd, Stockport, United Kingdom, 9Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom, 10Department of Medicine, Imperial College London, London, United Kingdom

UK Biobank is a prospective epidemiological study of 500,000 participants consisting of extensive questionnaires, physical measures and biological samples, linking to long-term health outcomes. The imaging extension for the UK Biobank ultimately aims to image 100,000 subjects from this cohort, including brain, cardiac and body MRI, bone scans and carotid ultrasound. We overview the brain imaging component, which includes structural, functional and diffusion MRI. The value of this open resource arises not only from multi-modal/multi-organ imaging, but also from the depth of other demographic, phenotypic and exposure data, and will increase over time as clinical outcomes are realized in the population.

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