Abstract #0328

On the Relationship between Cellular and Hemodynamic Properties of the Human Brain Cortex over Adult Lifespan

Yue Zhao¹, Jie Wen², Anne Cross³, and Dmitriy Yablonskiy²

¹Chemistry, Washington University in St. Louis, St. Louis, MO, United States, ²Radiology, Washington University in St. Louis, St. Louis, MO, United States, ³Neurology, Washington University in St. Louis, St. Louis, MO, United States

Establishing baseline MRI biomarkers for normal brain aging is significant and valuable. In this study, we use previously developed approach to measure tissue-specific transverse relaxation rate constant (R2*_t) and BOLD contributions to GRE signal, thus providing information on tissue cellular and hemodynamic properties. The VSF approach is applied for background gradient correction together with navigator echo to minimize artifacts from physiological fluctuations. Our results show age-related R2*_t increases in most cortical regions and age-independent behavior of most hemodynamic parameters. We hypothesize that R2*_t could serve as a biomarker of the cortical “cellular packing density”, which mostly reflects the neuronal density.

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