Multi-parameter mapping, fat/water separation and functional imaging with a two-sequence brain morphometry protocol
Andre Jan Willem van der Kouwe1, Fikret Isik Karahanoglu1, Matthew Dylan Tisdall1, Paul Wighton1, Himanshu Bhat2, Thomas Benner3, and Jonathan R Polimeni1
1Athinoula A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Siemens Healthcare, Charlestown, MA, United States, 3Siemens Healthcare, Erlangen, Germany
We
present an efficient two-sequence protocol for quantifying multiple parameters
in a 1 mm isotropic brain morphometry examination. The protocol comprises a
multiple gradient echo (TE), multiple inversion (TI) time MPRAGE (MEMPxRAGE)
and a two-flip-angle balanced SSFP (TrueFISP) sequence. Proton density and T1 maps
are estimated from the MEMPxRAGE data using the multi-TI data and a Bloch
simulation. With the T1 map and TrueFISP data, the T2 map is estimated using
DESPOT2. Fat, water and B0 maps are obtained from the multi-TE data using the
IDEAL algorithm. The MEMPxRAGE scan
includes embedded 3D EPI-based navigators encoding low resolution functional
information.
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