Abstract #0331

Multi-parameter mapping, fat/water separation and functional imaging with a two-sequence brain morphometry protocol

Andre Jan Willem van der Kouwe¹, Fikret Isik Karahanoglu¹, Matthew Dylan Tisdall¹, Paul Wighton¹, Himanshu Bhat², Thomas Benner³, and Jonathan R Polimeni¹

¹Athinoula A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Siemens Healthcare, Charlestown, MA, United States, ³Siemens Healthcare, Erlangen, Germany

We present an efficient two-sequence protocol for quantifying multiple parameters in a 1 mm isotropic brain morphometry examination. The protocol comprises a multiple gradient echo (TE), multiple inversion (TI) time MPRAGE (MEMPxRAGE) and a two-flip-angle balanced SSFP (TrueFISP) sequence. Proton density and T₁ maps are estimated from the MEMPxRAGE data using the multi-TI data and a Bloch simulation. With the T₁ map and TrueFISP data, the T₂ map is estimated using DESPOT2. Fat, water and B0 maps are obtained from the multi-TE data using the IDEAL algorithm. The MEMPxRAGE scan includes embedded 3D EPI-based navigators encoding low resolution functional information.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.