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Abstract #0331

Multi-parameter mapping, fat/water separation and functional imaging with a two-sequence brain morphometry protocol

Andre Jan Willem van der Kouwe1, Fikret Isik Karahanoglu1, Matthew Dylan Tisdall1, Paul Wighton1, Himanshu Bhat2, Thomas Benner3, and Jonathan R Polimeni1

1Athinoula A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Siemens Healthcare, Charlestown, MA, United States, 3Siemens Healthcare, Erlangen, Germany

We present an efficient two-sequence protocol for quantifying multiple parameters in a 1 mm isotropic brain morphometry examination. The protocol comprises a multiple gradient echo (TE), multiple inversion (TI) time MPRAGE (MEMPxRAGE) and a two-flip-angle balanced SSFP (TrueFISP) sequence. Proton density and T1 maps are estimated from the MEMPxRAGE data using the multi-TI data and a Bloch simulation. With the T1 map and TrueFISP data, the T2 map is estimated using DESPOT2. Fat, water and B0 maps are obtained from the multi-TE data using the IDEAL algorithm. The MEMPxRAGE scan includes embedded 3D EPI-based navigators encoding low resolution functional information.

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