Reproducibility of fast three-dimensional macromolecular proton fraction mapping of the human brain: global tissue characterization and volume measurements
Vasily L. Yarnykh1,2
1Radiology, University of Washington, Seattle, WA, United States, 2Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation
A
new method for fast high-resolution whole-brain three-dimensional
(3D) mapping of the macromolecular proton fraction (MPF) based on three source
images has been recently proposed. In this study, reproducibility of repeated MPF
measurements in white and gray matter with simultaneous estimation of tissue
volumes using automated segmentation of 3D MPF maps obtained with isotropic
resolution of 1.25 mm was assessed. MPF
measurements in brain tissues are highly reproducible with coefficients of
variation <1.5%. 3D MPF mapping provides “all-in-one” solution for simultaneous
characterization of myelination and volumetric changes in brain tissues.
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