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Abstract #0332

Reproducibility of fast three-dimensional macromolecular proton fraction mapping of the human brain: global tissue characterization and volume measurements

Vasily L. Yarnykh1,2

1Radiology, University of Washington, Seattle, WA, United States, 2Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation

A new method for fast high-resolution whole-brain three-dimensional (3D) mapping of the macromolecular proton fraction (MPF) based on three source images has been recently proposed. In this study, reproducibility of repeated MPF measurements in white and gray matter with simultaneous estimation of tissue volumes using automated segmentation of 3D MPF maps obtained with isotropic resolution of 1.25 mm was assessed. MPF measurements in brain tissues are highly reproducible with coefficients of variation <1.5%. 3D MPF mapping provides “all-in-one” solution for simultaneous characterization of myelination and volumetric changes in brain tissues.

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