Abstract #0333

Automated Measurements of Brain Morphometry Derived from T1-weighted Magnetic Resonance Imaging Fluctuate from Morning to Afternoon

Aaron Trefler¹, Neda Sadeghi², Adam Thomas¹, Carlo Pierpaoli², Chris Baker¹, and Cibu Thomas³

¹National Institute of Mental Health, Bethesda, MD, United States, ²National Institute of Child Health and Human Development, Bethesda, MD, United States, ³Center for Neuroscience and Regenerative Medicine, Bethesda, MD, United States

Automated measures of brain morphometry derived from T1-weighted (T1W) images are typically used as proxy measures to investigate the relation between brain structure and behavior. However, the computation of T1W morphometric measures can be influenced by subject-related factors such as head motion¹ and level of hydration². Here, we provide a comprehensive assessment of the impact of time-of-day (TOD) on widely used measures of brain morphometry in healthy young adults. Our results show that the apparent volume of all major tissue compartments as well as measures of brain morphometry such as cortical thickness and gray matter density are significantly influenced by TOD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.