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Abstract #0362

Multifrequency MR elastography for assessing hepatic fibrosis in pediatric non-alcoholic fatty liver disease

Jing Guo1, Christian Hudert2, Heiko Tzschätzsch1, Andreas Fehlner1, Florian Dittmann1, Jürgen Braun3, and Ingolf Sack1

1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

Multifrequency MR elastography (MMRE) was applied to 32 obese pediatric patients with non-alcoholic fatty liver disease (NAFLD). Magnitude shear modulus |G*| which relates to liver stiffness is sensitive to differentiate mild fibrosis (F0-2) from severe fibrosis (F3) with an AUROC of 0.93. The liver stiffness was positively correlated with serum alanine aminotransferase (ALT) and can potentially serve as a quantitative imaging marker for the noninvasive assessment of liver fibrosis in patients with NAFLD.

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