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Abstract #0365

Muscle functional oxidative capacity varies along the length of healthy tibialis anterior

Andreas Boss1, Linda Heskamp1, Mark Jacobus van Uden1, Lauren Jean Bains2,3, Vincent Breukels1, and Arend Heerschap1

1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, 3Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands

Traditional PCr recovery experiments are performed in a non-localized way, while skeletal muscle is not homogeneous. In this study we performed localized 31P-MRS using a ladder-shaped 31P-phased array receive coil optimized for the tibialis anterior and found a pronounced variation in the rate of PCr recovery after isometric exercise along the length of this muscle in healthy volunteers. In addition, we observed similar regional differences in the time-to-peak signal intensity of muscle functional MRI obtained after exercise in the same volunteers. The reasons for this strong functional gradient along the tibialis anterior remain, however, to be elucidated.

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