Abstract #0365

Muscle functional oxidative capacity varies along the length of healthy tibialis anterior

Andreas Boss¹, Linda Heskamp¹, Mark Jacobus van Uden¹, Lauren Jean Bains^2,3, Vincent Breukels¹, and Arend Heerschap¹

¹Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ³Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands

Traditional PCr recovery experiments are performed in a non-localized way, while skeletal muscle is not homogeneous. In this study we performed localized ³¹P-MRS using a ladder-shaped ³¹P-phased array receive coil optimized for the tibialis anterior and found a pronounced variation in the rate of PCr recovery after isometric exercise along the length of this muscle in healthy volunteers. In addition, we observed similar regional differences in the time-to-peak signal intensity of muscle functional MRI obtained after exercise in the same volunteers. The reasons for this strong functional gradient along the tibialis anterior remain, however, to be elucidated.

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