Abstract #0373

Longitudinal sodium MRI of cartilage in patients with knee osteoarthritis: Baseline vs. 16 months follow-up

Guillaume Madelin¹, Ding Xia¹, Gregory Chang¹, Svetlana Krasnokutsky², Steven B Abramson², and Ravinder R Regatte¹

¹Department of Radiology, New York University Langone Medical Center, New York, NY, United States, ²Department of Rheumatology, New York University Langone Medical Center, New York, NY, United States

In this longitudinal study, we measured the sodium concentration in knee cartilage in 12 patients with osteoarthritis (OA) with quantitative ²³Na MRI at 7 T. Sodium measurements were performed at baseline and 16 months follow-up (on average), with and without fluid suppression by inversion recovery (IR). We show that only fluid-suppressed measurements show a significant decrease of mean [Na⁺] in different regions of cartilage over 16 months follow-up in OA patients. Quantitative ²³Na IR-MRI could therefore be a useful imaging biomarker to monitor cartilage degradation over time, and help assess the efficiency of potential disease modifying OA drugs.

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