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Abstract #0374

PCA-T1ρ Voxel-Based Relaxometry of the Articular Cartilage: a Comparison of Biochemical Pattern Changes in Knees with Osteoarthritis and ACL Injury

Valentina Pedoia1, Colin Russell1, Allison Randolph V1, Keiko Amano1, Xiaojuan Li1, and Sharmila Majumdar1

1University of California, San Francisco, San Francisco, CA, United States

MR quantitative T1ρ mapping has been extensively used to probe articular biochemical changes. While several studies are still limited to analyzing average T1ρ values, there is growing interest in the analysis of local patterns of T1ρ maps. A novel algorithm for locally studying knee relaxation times using Voxel-Based Relaxometry (VBR) was recently proposed. In this study we propose to couple VBR and Principal Component Analysis in order to analyze local pattern changes in OA and ACL patients. Specific features, behind the expected average elevation of T1ρ values, are observed able to distinguish between OA, ACL and Controls subjects.

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