Abstract #0375

Correlation of Bone Pathology on MRI with 18F-fluoride PET Uptake in Subchondral Bone

Feliks Kogan¹, Audrey Fan¹, Emily McWalter¹, Edwin Oei², Andrew Quon¹, and Garry Gold¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Radiology, Erasmus Medical Center, Rotterdam, Netherlands

Osteoarthritis (OA) is a debilitating disease that affects 27 million Americans, causing pain, stiffness and loss of mobility. Simultaneous PET-MR imaging provides an opportunity to combine metabolic information regarding bone remodeling with high resolution images on MR. This work demonstrates that simultaneous 18F-fluoride PET/MR may provide additional metabolic information regarding bone pathology seen on conventional MR. This will allow for a better understanding of the role of bone degeneration in OA disease processes. Additionally, 18F-fluoride PET/MR may detect knee abnormalities unseen on MRI alone and is a promising tool for detection of early metabolic changes in OA.

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