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Abstract #0375

Correlation of Bone Pathology on MRI with 18F-fluoride PET Uptake in Subchondral Bone

Feliks Kogan1, Audrey Fan1, Emily McWalter1, Edwin Oei2, Andrew Quon1, and Garry Gold1

1Radiology, Stanford University, Stanford, CA, United States, 2Radiology, Erasmus Medical Center, Rotterdam, Netherlands

Osteoarthritis (OA) is a debilitating disease that affects 27 million
Americans, causing pain, stiffness and loss of mobility. Simultaneous PET-MR imaging provides an opportunity to combine metabolic information regarding bone remodeling with high resolution images on MR. This work demonstrates that simultaneous 18F-fluoride PET/MR may provide additional metabolic information regarding bone pathology seen on conventional MR. This will allow for a better understanding of the role of bone degeneration in OA disease processes. Additionally, 18F-fluoride PET/MR may detect knee abnormalities unseen on MRI alone and is a promising tool for detection of early metabolic changes in OA.

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