Abstract #0376

Quantitative assessment of muscle metabolism and dynamics of oxygen consumption with vPIVOT

Erin Kristine Englund¹, Zachary Bart Rodgers¹, Michael C Langham², Emile R Mohler³, Thomas F Floyd⁴, and Felix W Wehrli²

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Anesthesiology, Stony Brook University, Stony Brook, NY, United States

A method to simultaneously measure blood flow, perfusion, venous oxygen saturation, and muscle T₂* using a 3-slice interleaved PASL, multi-echo GRE sequence is presented. The method, termed Velocity and Perfusion, Intravascular Venous Oxygen saturation and T₂* (vPIVOT) was assessed in five subjects during a series of ischemia-reperfusion paradigms. Results indicate that vPIVOT faithfully measures all four parameters at 4-second temporal resolution. Dynamic measurement of these parameters was completed following a bout of dynamic plantar flexion contractions. vPIVOT allows for quantification of muscle oxygen consumption and evaluation of macro/microvascular flow dynamics, and may be useful for the development of biophysical models.

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