Abstract #0383

Compressed Sensing Accelerated MR Spectroscopic Imaging of Lactate

Rohini Vidya Shankar¹, Shubhangi Agarwal¹, and Vikram D Kodibagkar¹

¹Biomedical Engineering, Arizona State University, Tempe, AZ, United States

Lactate plays a key role in the development and progression of tumors and its spatial profile can be mapped using magnetic resonance spectroscopic imaging (MRSI). However, the long scan time involved in MRSI acquisitions is a deterrent to its inclusion in routine clinical protocols. A MRSI sequence containing lactate editing components combined with prospective compressed sensing acquisitions was developed for fast mapping of lactate metabolism, particularly in response to treatment. Results from in vivo experiments demonstrate a reduction in acquisition time by up to 80%, with the accelerated MRSI datasets maintaining high fidelity with the fully sampled reference dataset.

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