Lactate plays a key role in the development and
progression of tumors and its spatial profile can be mapped using magnetic
resonance spectroscopic imaging (MRSI). However,
the long scan time involved in MRSI acquisitions is a deterrent to its
inclusion in routine clinical protocols. A MRSI sequence containing lactate
editing components combined with prospective compressed sensing acquisitions was
developed for fast mapping of lactate metabolism, particularly in response to
treatment. Results from in vivo
experiments demonstrate a reduction in acquisition time by up to 80%, with the
accelerated MRSI datasets maintaining high fidelity with the fully sampled
reference dataset.
