Abstract #0382

Multiband Spectral-Spatial RF Excitation for Hyperpolarized [2‑13C]Dihydroxyacetone 13C-MR Metabolism Studies

Irene Marco-Rius¹, Peng Cao¹, Cornelius von Morze¹, Matthew Merritt², Karlos X Moreno³, Gene-Yuan Chang⁴, Michael A Ohliger¹, David Pearce⁴, John Kurhanewicz¹, Peder EZ Larson¹, and Daniel B Vigneron¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States, ³Department of Chemistry, Engineering, Pre-Pharmacy, and Physics, South Texas College, Weslaco, TX, United States, ⁴Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, CA, United States

¹³C-MR spectra of hyperpolarized [2-¹³C]dihydroxyacetone (DHAc), a new agent for imaging gluconeogenesis, was acquired using specialized acquisition methods in the rat liver and kidney in vivo. Because the resonances originating from the metabolism of [2-¹³C]DHAc have a large frequency distribution, we designed a novel spectral-spatial (SPSP), multi-band excitation pulse that corrects for chemical shift misregistration, resulting in accurate spatial-spectral selectivity. The metabolic products phosphoenolpyruvate (PEP) and glycerol 3-phosphate (G3P) were detected, evidencing metabolism of the hyperpolarized substrate towards the glycolytic pathway and activity of the enzyme glycerol 3-phosphate dehydrogenase.

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