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Abstract #0381

Multi-slice functional FID based spectroscopic imaging on mice using dynamic shimming at 9.4T

Aline Seuwen1, Markus Wick2, Franek Hennel1, Aileen Schroeter1, and Markus Rudin1,3

1Institute for biomedical engineering, ETH & University of Zürich, Zürich, Switzerland, 2Bruker BioSpin MRI GmbH, Ettlingen, Germany, 3Institute for pharmacology and toxicology, University of Zürich, Zürich, Switzerland

In order to increase the volume coverage of 2D FID based spectroscopic imaging in mice i.e. the simultaneous measurement of several brain slices, we implemented a dynamic shimming approach involving the separate optimization of first and second order shim terms for volumes of interest in individual slices. When acquiring two slices covering cortical and thalamic regions similar spectra quality has been observed in both slices using dynamic shimming as compared to measuring each slice individually. This allows simultaneous acquisition of metabolite signal changes in several brain regions associated with stimulus evoked neural activity upon sensory stimulation.

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