Multi-slice functional FID based spectroscopic imaging on mice using dynamic shimming at 9.4T
Aline Seuwen1, Markus Wick2, Franek Hennel1, Aileen Schroeter1, and Markus Rudin1,3
1Institute for biomedical engineering, ETH & University of Zürich, Zürich, Switzerland, 2Bruker BioSpin MRI GmbH, Ettlingen, Germany, 3Institute for pharmacology and toxicology, University of Zürich, Zürich, Switzerland
In order to increase the volume coverage of 2D FID
based spectroscopic imaging in mice i.e. the
simultaneous measurement of several brain slices, we implemented a dynamic
shimming approach involving the separate optimization of first and second order
shim terms for volumes of interest in individual slices. When acquiring two
slices covering cortical and thalamic regions similar spectra
quality has been observed in both slices using dynamic shimming as compared to
measuring each slice individually. This allows simultaneous acquisition of metabolite
signal changes in several brain regions associated with stimulus evoked neural
activity upon sensory stimulation.
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