Abstract #0400

Breast tissue lipid and metabolite deregulation precedes malignant transformation in women with BRCA gene mutations: a longitudinal study

Gorane Santamaria¹, Jessica Buck^2,3, Leah Best⁴, David Clark⁵, Judith Silcock⁵, Peter Lau⁴, Saadallah Ramadan⁶, Scott Quadrelli^3,7, Peter Malycha³, and Carolyn Mountford³

¹Hospital Clinic de Barcelona, Barcelona, Spain, ²Oxford University, Oxford, United Kingdom, ³Translational Research Institute, Brisbane, Australia, ⁴Hunter New England Area Health, Newcastle, Australia, ⁵The Breast and Endocrine Centre, Gateshead, Gateshead, Australia, ⁶University of Newcastle, Australia, Newcastle, Australia, ⁷Queensland University of Technology, Brisbane, Australia

Women carrying the BRCA1 and BRCA2 gene mutations exhibited lipid and metabolite profiles consistent with very early deregulation recorded earlier in cancer cell models. The deregulation was different for BRCA1 and BRCA2. Here we report a longitudinal study where these same women are monitored every six month using the L-COSY MRS method and every 12 month with contrast enhanced MRI. For most women in the study the biomarkers remained relatively stable over time. Of the 6 BRCA1 and 10 BRCA2 patients examined, one BRCA1 patient and one BRCA2 patient showed further deregulation.

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