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Abstract #0400

Breast tissue lipid and metabolite deregulation precedes malignant transformation in women with BRCA gene mutations: a longitudinal study

Gorane Santamaria1, Jessica Buck2,3, Leah Best4, David Clark5, Judith Silcock5, Peter Lau4, Saadallah Ramadan6, Scott Quadrelli3,7, Peter Malycha3, and Carolyn Mountford3

1Hospital Clinic de Barcelona, Barcelona, Spain, 2Oxford University, Oxford, United Kingdom, 3Translational Research Institute, Brisbane, Australia, 4Hunter New England Area Health, Newcastle, Australia, 5The Breast and Endocrine Centre, Gateshead, Gateshead, Australia, 6University of Newcastle, Australia, Newcastle, Australia, 7Queensland University of Technology, Brisbane, Australia

Women carrying the BRCA1 and BRCA2 gene mutations exhibited lipid and metabolite profiles consistent with very early deregulation recorded earlier in cancer cell models. The deregulation was different for BRCA1 and BRCA2. Here we report a longitudinal study where these same women are monitored every six month using the L-COSY MRS method and every 12 month with contrast enhanced MRI. For most women in the study the biomarkers remained relatively stable over time. Of the 6 BRCA1 and 10 BRCA2 patients examined, one BRCA1 patient and one BRCA2 patient showed further deregulation.

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