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Abstract #0401

Fat-Based Registration of Breast DCE Water Images

Subashini Srinivasan1, Brian A Hargreaves1, and Bruce L Daniel1

1Radiology, Stanford University, Stanford, CA, United States

Three-dimensional breast dynamic contrast-enhanced imaging is susceptible to deformable motion and affects both semi-quantitative and pharmacokinetic parameters. B-Spline motion registration with a mutual information metric is often used to register DCE images but is sometimes susceptible to introduction of new motion. Here we have introduced a fat-based motion registration, using a mean-squared-difference signal metric, to register the water images without introducing new motion. The acquired images and both registration methods were qualitatively assessed in 16 breasts. Voxel-by-voxel pharmacokinetic mapping was also performed in 21 tumors. Our results show that fat-based registration can be used to register the water images with improved image quality and reduced errors in quantification.

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