Abstract #0407

Different anti-angiogenic drugs have different effects on the relationship between vascular structure and function in a patient-derived breast cancer model

Eugene Kim¹, Jana Cebulla¹, Astrid Jullumstrø Feuerherm², Berit Johansen², Olav Engebråten³, Gunhild Mari Mælandsmo³, Tone Frost Bathen¹, and Siver Andreas Moestue¹

¹MR Cancer Group, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, ²Avexxin AS, Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway, ³Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway

This study investigated the relationship between tumor vascular function (DCE-MRI) and structure (ex vivo micro-CT). Control tumors did not exhibit any significant correlations between micro-CT and DCE-MRI parameters. Tumors treated with bevacizumab or a cPLA2 inhibitor (AVX235), both anti-angiogenic drugs, displayed reduced perfusion and vascularization. But interestingly, there was a significant positive correlation between vascular surface area and Ktrans in AVX235-treated tumors, whereas the corresponding correlation was negative in bevacizumab-treated tumors. This suggests that different therapies can differentially modulate the vascular structure-function relationship, which highlights the challenge in interpreting DCE-MRI measurements and adopting them as clinical biomarkers of therapeutic response.

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