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Abstract #0407

Different anti-angiogenic drugs have different effects on the relationship between vascular structure and function in a patient-derived breast cancer model

Eugene Kim1, Jana Cebulla1, Astrid Jullumstrø Feuerherm2, Berit Johansen2, Olav Engebråten3, Gunhild Mari Mælandsmo3, Tone Frost Bathen1, and Siver Andreas Moestue1

1MR Cancer Group, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, 2Avexxin AS, Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway, 3Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway

This study investigated the relationship between tumor vascular function (DCE-MRI) and structure (ex vivo micro-CT). Control tumors did not exhibit any significant correlations between micro-CT and DCE-MRI parameters. Tumors treated with bevacizumab or a cPLA2 inhibitor (AVX235), both anti-angiogenic drugs, displayed reduced perfusion and vascularization. But interestingly, there was a significant positive correlation between vascular surface area and Ktrans in AVX235-treated tumors, whereas the corresponding correlation was negative in bevacizumab-treated tumors. This suggests that different therapies can differentially modulate the vascular structure-function relationship, which highlights the challenge in interpreting DCE-MRI measurements and adopting them as clinical biomarkers of therapeutic response.

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