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Abstract #0412

Using intrinsic Cardiac Shear Waves to measure Myocardial Stiffness: Initial results on a Patient Cohort with Heart failure with preserved Ejection Fraction

Jessica Webb1, Ondrej Holub1, Rachel Clough1, Gerald Carr-White2, Reza Razavi1, and Ralph Sinkus1

1King's College London, London, United Kingdom, 2Guys and St Thomas' NHS Trust, London, United Kingdom

Heart Failure with preserved Ejection Fraction (HFpEF) is common and associated with high morbidity and mortality. There are challenges in diagnosing HFpEF and a non invasive technique to detect myocardial stiffness would have an enormous clinical impact.

We have developed a novel non invasive technique to quantify myocardial stiffness in vivo using transient Magnetic Resonance Elastography (tMRE). The technique relies on accurately identifying the aortic valve closure time. The speed of the propagating shear wave, created by the valve closure, is measured using a short navigated free breathing MRI sequence. Increased myocardial stiffness results in increased speed of shear wave propagation.

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