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Abstract #0413

Three-Dimensional Modelling of the Fetal Vasculature from Prenatal MRI using Motion-Corrected Slice-to-Volume Registration

David F A Lloyd1,2, Bernhard Kainz3, Joshua F P van Amerom1, Kuberan Pushparajah1,2, John M Simpson2, Vita Zidere2, Owen Miller2, Gurleen Sharland2, Tong Zhang1, Maelene Lohezic1, Joanne Allsop1, Matthew Fox1, Christina Malamateniou1, Mary Rutherford1, Jo Hajnal1, and Reza Razavi1,2

1Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2Evelina Children's Hospital, London, United Kingdom, 3Department of Computing (BioMedIA), Imperial College London, London, United Kingdom

The diagnosis of potentially life-threatening vascular abnormalities in the fetus can be difficult with ultrasound alone. MRI is one of the few safe alternative imaging modalities in pregnancy; however to date it has been limited by unpredictable fetal and maternal motion during acquisition. We present six antenatal cases, four with important structural congenital heart disease, in which we employed a novel algorithm for motion-corrected slice-volume registration, producing a navigable 3D volume of the fetal thoracic vasculature. The anatomical findings in each case were then correlated to fetal echocardiographic findings, and finally displayed as interactive surface rendered models.

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