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Abstract #0418

A differential arterial blood volume response during Lower Body Negative Pressure measured using Pulsed Arterial Spin Labelling with multiple short inversion times

Joseph R Whittaker1, Molly G Bright1,2, Ian D Driver1, Adele Babic1,3, Martin Stuart1, and Kevin Murphy1

1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3Department of Anesthesia and Intensive Care Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom

A custom made MRI compatible lower body negative pressure (LBNP) chamber induced central hypovolemia in a group of healthy volunteers. Pulsed ASL data with multiple short inversion times was acquired during a baseline period and -40mmHg LBNP in order to estimate arterial cerebral blood volume changes related to cerebral autoregulation. We found a differential response, in which arterial blood volume changes during LBNP were dependent on vessel size. These data provide a useful first step for fully understand the complex vascular changes that occur in the brain to maintain perfusion during systemic physiological perturbations.

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